I.Original Innovation Leads · Defines the Era

     Before 2003, mainstream hospital-grade EEG (electroencephalography) systems worldwide remained predominantly wired.

     That year, NCC MEDICAL pioneered the world's first wireless Bluetooth video-EEG system, achieving a complete closed-loop integration of wireless communication + video synchronization + 24-hour ambulatory monitoring . This landmark innovation officially inaugurated the era of wireless and intelligent neuroelectrophysiology. The system underwent clinical validation in neurology departments and epilepsy centers of multiple Grade A tertiary hospitals and obtained medical device registration certificates  and patent certifications .

     Subsequent consumer and research-grade wireless devices propelled the adoption of wearable EEG. However, these devices fundamentally differ from NCC’s 2003 clinical-grade system in targeting and regulatory compliance, as NCC’s solution was explicitly designed for clinical use and holds valid registrations and patents .

     NCC MEDICAL drove a historic shift in EEG monitoring from static wired recording to wireless intelligent monitoring through original technologies.

We are not followers—we are pioneers.

     To ensure transparency and verifiability of historical facts, this page provides links to third-party documentation and academic reviews for reference.

II.Authoritative Endorsement · Original Facts

（1）Utility Model Patent

Patent Number：ZL 03 2 28127.7  Publication Number： CN2604152Y

Patent Title：Wireless Bluetooth Electroencephalograph

Filing Date: January 10, 2003

Authorization Announcement Date: February 25, 2004

This is China’s earliest utility model patent for "wireless Bluetooth electroencephalographs", which fully confirms the originality and chronological pioneering nature of NCC’s technology.

（2）Medical Device Registration Certificate

Registration Number：沪食药监械（准）字 2004 第 2210380 号

Product Name: Video Electroencephalograph (including wireless Bluetooth version)

Approving Authority: Shanghai Food and Drug Administration

Function Description: Supports 24-hour ambulatory monitoring, video synchronization, and wireless data transmission

This product is an officially approved and marketed medical device, with legal qualification for clinical use.

（3）Invention Patent

Patent Number：ZL 2006 1 0027655.3

Invention Title: Brain Electrical Detection Device Combining Hardware and Software

Filing Date: June 13, 2006

Authorization Date: July 22, 2009

This invention patent reinforces NCC’s core technological barriers in the architecture of EEG systems and the collaboration between hardware and software.

III.Third-Party Verification · Clear Historical Comparison

     NCC MEDICAL's first wireless Bluetooth video EEG system filed a patent in 2003 (Patent No.: CN2604152Y) and obtained clinical registration approval from Shanghai Food and Drug Administration in 2004.

     By comparison, Nihon Kohden's WEE-1000 was launched in 2004, obtained medical device registration certificate in Japan and went on the market in 2007. NeuroSky MindSet (2007 – 2009) and Emotiv EPOC (2009) represent scientific research/consumer-grade products. The earliest regulatory records of Natus' wireless models, Nicolet Wireless 32/64 and EMU40EX, are 2015 and 2016 respectively.

     In conclusion, NCC leads in terms of R&D timeline in the field of wireless Bluetooth clinical EEG.

     The following are the representative products of various manufacturers and verifiable public sources:

• NCC MEDICAL (Wireless Bluetooth Video Electroencephalography System)

     Patent: Wireless Bluetooth Electroencephalograph – Utility Model Patent

     Description: This is a public patent document from the China National Intellectual Property Administration (CNIPA), which confirms that NCC proposed the design of the "Wireless Bluetooth Electroencephalograph" in 2003.

• Medical Device Registration Certificate: Video Electroencephalograph (Including Wireless Bluetooth Version)

     Registration Number：沪食药监械（准）字 2004 第 2210380 号

     Approving Authority: Shanghai Food and Drug Administration

     Model: NATION 7128W / 7128WH

     Approval Date: 2004-11-16

     Description: It shows that this model obtained an official Medical Device Registration Certificate in 2004 and is a clinically-grade device approved by the regulatory authority.

• Nihon Kohden

     WEE-1000 Wireless EEG Unit（2004）

     Company History — 2000s | Nihon Kohden Global Site

     Description: The company's history section states that "in 2004 — World’s first wireless EEG (WEE - 1000)" was the first official wireless EEG recording.

• NeuroSky

     MindSet / MindWave（2007 – 2009）

     NeuroSky — Wikipedia Overview

     Genaro Rebolledo-Mendez(2009)-Assessing NeuroSky’s Usability to Detect Attention Levels in an Assessment Exercise

     Description: The prototype was developed in 2007, and the device was launched for commercial use in 2009. Academic papers have verified its applications in education and research.

• Emotiv

     EPOC (2009) / EPOC+ (2013)

     Emotiv — Wikipedia Entry 

     Badcock et al., 2015 — Validation of the Emotiv EPOC EEG system for research quality auditory event-related potentials in children

     Description: The EPOC was launched in 2009, and the EPOC+ introduced Bluetooth Low Energy (BLE) in 2013; its applications have been widely verified by academic research.

• Natus / Bio-Logic (Nicolet, XLTEK)

     Nicolet Wireless EEG Amplifier(2011)

     Approval Letter before Market Launch and Summary Document(Apr 8 2011)

     Nicolet EEG Wireless 32/64 Amplifier（≈2015）

     FCC Report — Natus Nicolet EEG Wireless 32/64 Amplifier Manual (Apr 27 2015)

     Description: According to the official manual, it was one of the first - batch EEG amplifiers with wireless transmission in 2015.

• XLTEK / Natus EMU40EX Wireless LTM Amplifier

     Natus Official Product Page 

     FDA 510(k) K163163 — Submission Date 2016-11-03

     Description: FDA regulatory documents confirm that the EMU40EX was submitted in 2016; the product manual clearly specifies "Bluetooth wireless connection".

IV.Technical Inheritance · Unceasing Innovation

NCC Product Development Timeline

For thirty years, we have focused on forging a single "sword"—every step we took has kept pace with the rhythm of technological transformation.

V. Independent Ecosystem · Intelligent Integration

     NCC MEDICAL has built a complete neuroelectrophysiology ecosystem covering “equipment + consumables + software + services”:

• Independently developed core consumables such as EEG electrodes, needle electrodes, and recurrent laryngeal nerve electrodes;

• Launched the world's first non-imaging electrode dedicated to interventional surgeries；

• Its consumables subsidiary, Shanghai Yingshou, was awarded the title of "Shanghai Specialized, Refined, Peculiar, and Innovative Little Giant Enterprise";

• Continuously developed AI signal analysis platforms, forming an intelligent diagnosis and treatment closed loop featuring "hardware as the foundation, software as the enabler"；

• Established a service center network in 31 provincial capital cities nationwide, covering clinical users.

We actively expand our global distributor network, commit to providing localized support and agile services for international clients, and advance our global layout.

VI.Industry Recognition · Technological Responsibility

VII. Academic Review and Timeline Comparison

     In recent years, several authoritative reviews have systematically summarized the development of wireless/portable EEG technology (Frontiers in Neuroscience, 2023; MDPI Sensors, 2022) and outlined the technological evolution timeline of EEG, from early wearable prototypes to modern high-throughput wireless systems.

     These literatures indicate that prior to 2003, there were no publicly released clinical-grade wireless EEG products based on Bluetooth—this stands in stark contrast to the timeline of NCC Medical, which obtained the registration certificate and patent for its (corresponding) product in 2003.

[1] Casson A.J. (2023). Wearable EEG systems and wireless signal quality: a review. Frontiers in Neuroscience, 17: 1100409.

    ⚠ Access Note : As of October 2025, the article's DOI page displays a 404 error, possibly due to journal migration or temporary editorial office page unavailability. The bibliographic information for this review is preserved in the CrossRef and PubMed databases, confirming its publication in Frontiers in Neuroscience in 2023 and its citation by multiple subsequent papers. Citing this entry as a review on wireless EEG signal quality and system evolution does not affect its academic validity.

[2] Congying He(2023). Diversity and Suitability of the State-of-the-Art Wearable and Wireless EEG Systems Review

     This paper systematically reviews the development of wireless EEG technology ,and evaluates the current state-of-the-art wearable and wireless electroencephalography (EEG) systems, with a focus on analyzing their technical diversity and exploring how to select the most suitable system based on different application scenarios.

[3] FDA 510(k) K163163 — Submission Date 2016-11-03

     FDA regulatory documents of Natus Medical Incorporated DBA Excel-tech Ltd. 

[4] Badcock et al., 2015 — Validation of the Emotiv EPOC EEG System

     This article mainly verifies the ability of the Emotiv EPOC head-mounted device to record research-grade event-related potentials (ERPs) in the child population.

[5]  FCC Report — Natus Nicolet EEG Wireless 32/64 Amplifier Manual (Apr 27 2015)

     Marked in the official manual as 2015, it is among the first batch of EEG amplifiers with wireless transmission function.

[6] Approval Letter before Market Launch and Summary Document(Apr 8 2011)

     This is a "Pre-Market Approval Letter" and a "Summary Document" for Nicolet EEG Wireless Aplifier issued by the U.S. Food and Drug Administration (FDA) in 2011.

[7] NeuroSky（2009） — Wikipedia Overview

     In the company history section, it is stated that "NeuroSky launches the MindSet, research and developer multimedia headset and free SDK/developer tools.”

[8] Genaro Rebolledo-Mendez(2009)-Assessing NeuroSky’s Usability to Detect Attention Levels in an Assessment Exercise

     This article aims to explore whether the NeuroSky MindSet can reliably detect changes in users' attention levels when they perform specific cognitive tasks.

[9] Emotiv — Wikipedia Entry(2009)

     In the history section, it is stated that”The work resulted in the first version of the EPOC neuroheadset released in 2009 one of the first mobile EEG device available to the market.”

[10] Company History（2004） — 2000s | Nihon Kohden Global Site

     In the company history section, it is stated that "2004 — World’s first wireless EEG (WEE-1000)", which marks the official first wireless EEG recording.

[11] Patent（2003）:Wireless Bluetooth Electroencephalograph - Utility Model Patent

     This is a patent document publicly available on China National Intellectual Property Administration. It confirms that NCC proposed the design of a "wireless Bluetooth electroencephalograph" in 2003.

NCC MEDICAL: From a pioneer in wireless technology to a driver of intelligent neuro-monitoring.

We use scientific research and innovation to write the world's firsts in China's neuroelectrophysiology.

About NCC Medical Co.,Ltd

     For 28 years, NCC Medical has focused on tackling key challenges in electrophysiological technology and developing related products. Adhering to the core value of "Commitment,Sincerity,Integrity," the company has continuously launched high-end electrophysiological equipment with independent intellectual property rights, driving the development of the electrophysiology industry. Its independently developed product—the first domestically made neurostimulation monitor specifically designed for intraoperative use in orthopedics and neurosurgery—has achieved a major breakthrough in domestic manufacturing and broken the barrier of reliance on imported equipment. Looking ahead, in the field of intraoperative electrophysiology, NCC Medical aims to strengthen industry-academia-research cooperation with clinical institutions, advance the development of cutting-edge technologies in this field, and provide higher-quality services for patients.

     As a "National-level Specialized, Refined, Differential, and Innovative Little Giant Enterprise" recognized by the Ministry of Industry and Information Technology, NCC Medical has always adhered to independent innovation and lean manufacturing, and built a full-chain independent and controllable system covering core technology R&D to key component production. The company's consumables subsidiary, Shanghai Yingshou Medical Device Co., Ltd., has also been awarded the title of "Shanghai Municipal-level Specialized, Refined, Differential, and Innovative Little Giant Enterprise", which further strengthens the company's leading advantages in the collaborative innovation of equipment and consumables.

     NCC Medical attaches great importance to technological innovation and clinical value. Its independently developed intraoperative  neuromonitoring and 256 high-channel event-related potential digital EEG capable of assisting cognitive diagnosis have both been included in the Shanghai Innovative Medical Devices Catalog . This marks that the products have obtained authoritative recognition in terms of technological advancement, clinical urgency, and quality and safety standards.